A 22-year-old male is brought in by ambulance after being found confused at the park. You note in his medical records that he has a background of bipolar disorder on lithium and olanzapine. Vital signs:

  • HR 136 bpm
  • BP 161/100
  • RR 24
94 % RA T 39.1 On examination, you find that the patient has lead-pipe rigidity. You are concerned that he has neuroleptic malignant syndrome.

1. List (5) differential diagnoses you would consider in this patient. 5 marks

2. What are (4) risk factors for developing neuroleptic malignant syndrome? 4 marks

3. Other than muscle rigidity, list (3) other criteria required to make a diagnosis of NMS? 3 marks

4. List (2) specific therapies that can be used to treat NMS 2 marks

5. Complete the table, listing (4) clinical features which would distinguish NMS from serotonin syndrome 4 marks