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Short Answer Questions for ED Fellowship Study

Case: Tumor lysis syndrome

A 59-year-old male was brought to your emergency department by ambulance after suffering a brief tonic-clonic seizure. He has been unwell with lethargy and vomiting after undergoing his first session of chemotherapy for a newly diagnosed malignancy a few days ago. His observations are : GCS 15 T 37.9 HR 120 BP 105/60 RR 26 Sats 95% RA You suspect tumour lysis syndrome as a cause of his symptoms.

1. List (4) risk factors for the development of tumour lysis syndrome. (4 marks)Break this down into :1. Tumour characteristics2. Chemo characteristics3. Patient factors4. Specific biochemical markers 4 marks

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2. List (4) biochemical findings on lab results to support your suspected diagnosis. (4 marks)Lab tests confirm tumour lysis syndrome. 4 marks

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3. List (5) treatments for the correction of the biochemical abnormalities. Explain your rationale. State no more than (2) options for each abnormality. (10 marks) 10 marks

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This case forms part of a collaborative marking project designed to support fellowship preparation. In the week leading up to each tutorial, you can contribute answers to any active case. If you contribute, your answers may be reviewed, marked, and used to refine the model answers during the weekly fellowship teaching sessions.

All responses are displayed anonymously or using anonymised avatars. You remain in full control of your answers and may withdraw them at any time.

Your personal results and updated model answers become available the day after the tutorial.

After the tutorial you can still do the case and self-mark your answers, but your answers will not be included in the group review.