Your intern is assessing a 31-year-old man with opioid use disorder who is seeking referral to an opioid replacement therapy (ORT) program. The patient is currently not on treatment but has previously trialled both methadone and Suboxone. He has never used depot buprenorphine.

1. What factors influence the use of ORT? Give (3) please. 3 marks

2. What are the relative benefits and risks of each ORT? Complete the table below. 6 marks

3. What factors increase the risk of overdose in patients receiving ORT? Please give (3). 3 marks