A 25-year-old man with sickle cell disease presents with non-productive cough, severe central chest pain and hypoxia. Vitals are as follows : T 38.0°C

  • HR 120
  • BP 110/65
  • RR 28
  • Sats 88% RA

Chest pain in sickle cell disease

1. What is the most concerning diagnosis in this patient? 1 mark

2. Excluding infection, list two possible precipitants for this presentation. 2 marks

3. State four initial management priorities for this patient with justification. 4 marks

4. List three other acute crises which may occur in patients with sickle cell disease. 3 marks

5. List two indications for exchange transfusion in sickle cell crisis. 2 marks