A 36-year-old man with intravenous drug use presents with fever and malaise for three days. His observations are as follows: T38.5, HR 118, BP 101/58, RR 22, Saturations 93% RA You are concerned about infective endocarditis.

1. Outline two major Duke criteria for the diagnosis of infective endocarditis. 2 marks

2. Outline four minor Duke criteria for the diagnosis of infective endocarditis. 4 marks

3. List three organisms that could be expected on blood culture in this patient. 3 marks

You decide to start empirical antibiotic therapy for infective endocarditis. The patient has had no previous cardiac surgery and has no allergies.

4. List three antibiotics including doses you would prescribe empirically. 3 marks

5. List six potential complications of infective endocarditis. 6 marks