A 4-year-old boy attends the Emergency Department with a 1-week history of fever and bloody diarrhoea. He is seen by one of your advanced trainees. A FBC is performed : Hb 75 Plt 20 WCC 14 Blood film – schistocytes ++ Coombs’ test negative The results are consistent with a microangiopathic haemolytic anaemia.

1. Other than Haemolytic Uraemic Syndrome (HUS), list (4) other causes of microangiopathic haemolytic anaemia (MAHA). (4 marks) 4 marks

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2. Complete the table below, outlining organ-specific complications of HUS. (5 marks) 5 marks

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3. Name a specific therapy that can be initiated in the treatment of severe disease. (1 mark) 1 mark

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You discuss the child’s presentation with the advanced trainee as part of their CBD for their WBA requirement. She asks you about the role of platelet transfusion in the context of HUS

4. Please outline your response. (2 marks) 2 marks

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